Metabolism Diazepam is N-demethylated by CYP3A4 and 2C19 for the active metabolite N-desmethyldiazepam, and is particularly hydroxylated by CYP3A4 into the Lively metabolite temazepam.You may need to maintain getting the drugs to steer clear of the withdrawal symptoms. This is named drug dependence.Opioids The concomitant usage of benzodiazepines a